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A non-carboxylative route for the efficient synthesis of central metabolite malonyl-CoA and its derived products - Nature Catalysis

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A non-carboxylative route for the efficient synthesis of central metabolite malonyl-CoA and its derived products - Nature Catalysis

Acetyl coenzyme A (CoA) carboxylation is the natural route for endogenous malonyl-CoA formation; however, this pathway presents slow kinetics, carbon and energy inefficiencies, tight regulations and a complicated architecture. These shortcomings limit flux towards malonyl-CoA and become a bottleneck towards the biosynthesis of malonyl-CoA-derived products (MDPs).

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A non-carboxylative route for the efficient synthesis of central metabolite malonyl-CoA and its derived products - Nature Catalysis

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A non-carboxylative route for the efficient synthesis of central metabolite malonyl-CoA and its derived products - Nature Catalysis

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