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The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts - Nature Structural & Molecular Biology
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Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a myriad of ways. Here, we review our understanding of the breadth of these changes from their effect on protein structure to their influence on interactions. These changes encompass effects on nucleic acid binding in the nucleus to protein–carbohydrate interactions in the extracellular milieu, altering interactions involving all major classes of biological molecules.
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