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A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle - Nature Communications

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A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle - Nature Communications

A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloacetate (OAA), a metabolically inactive form of OAA that is a strong inhibitor of succinate dehydrogenase. We purified from cow heart mitochondria an enzyme (OAT1) with OAA tautomerase (OAT) activity that converts enol-OAA to the physiological keto-OAA form, and determined that it belongs to the highly conserved and previously uncharacterized Fumarylacetoacetate_hydrolase_domain-containing protein family.

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A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle - Nature Communications

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A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle - Nature Communications

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