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7-Dehydrocholesterol is an endogenous suppressor of ferroptosis - Nature

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7-Dehydrocholesterol is an endogenous suppressor of ferroptosis - Nature

Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation1,2. Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC).

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7-Dehydrocholesterol is an endogenous suppressor of ferroptosis - Nature

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7-Dehydrocholesterol is an endogenous suppressor of ferroptosis - Nature

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