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High-throughput reprogramming of an NRPS condensation domain - Nature Chemical Biology

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High-throughput reprogramming of an NRPS condensation domain - Nature Chemical Biology

Engineered biosynthetic assembly lines could revolutionize the sustainable production of bioactive natural product analogs. Although yeast display is a proven, powerful tool for altering the substrate specificity of gatekeeper adenylation domains in nonribosomal peptide synthetases (NRPSs), comparable strategies for other components of these megaenzymes have not been described. Here we report a high-throughput approach for engineering condensation (C) domains responsible for peptide elongation.

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High-throughput reprogramming of an NRPS condensation domain - Nature Chemical Biology

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High-throughput reprogramming of an NRPS condensation domain - Nature Chemical Biology

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