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Large language models improve annotation of prokaryotic viral proteins - Nature Microbiology

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Large language models improve annotation of prokaryotic viral proteins - Nature Microbiology

Viral genomes are poorly annotated in metagenomic samples, representing an obstacle to understanding viral diversity and function. Current annotation approaches rely on alignment-based sequence homology methods, which are limited by the paucity of characterized viral proteins and divergence among viral sequences. Here we show that protein language models can capture prokaryotic viral protein function, enabling new portions of viral sequence space to be assigned biologically meaningful labels.

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Large language models improve annotation of prokaryotic viral proteins - Nature Microbiology

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Large language models improve annotation of prokaryotic viral proteins - Nature Microbiology

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