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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation - Nature Metabolism

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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation - Nature Metabolism

Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin resistance and fatty liver disease. Here we show that high-fat diet (HFD) feeding causes mitochondrial fragmentation in inguinal white adipocytes from male mice, leading to reduced oxidative capacity by a process dependent on the small GTPase RalA. RalA expression and activity are increased in white adipocytes after HFD.

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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation - Nature Metabolism

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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation - Nature Metabolism

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