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A molecular glue degrader of eRF1 on the ribosome - Nature Chemical Biology

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A molecular glue degrader of eRF1 on the ribosome - Nature Chemical Biology

SRI-41315 is a small molecule that enhances premature read-through of the stop codon by triggering the degradation of the translation termination factor eRF1. Cryo-EM structures and biochemical analyses reveal how SRI-41315 acts as a molecular glue between eRF1 and the decoding center of ribosomes, leading to increased recognition of the cryptic stop codon and eRF1 degradation.

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A molecular glue degrader of eRF1 on the ribosome - Nature Chemical Biology

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A molecular glue degrader of eRF1 on the ribosome - Nature Chemical Biology

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