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Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo - Cell Death & Disease

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Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo - Cell Death & Disease

Necroptosis, a type of lytic cell death executed by the pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) has been implicated in the detrimental inflammation caused by SARS-CoV-2 infection. We minimally and extensively passaged a single clinical SARS-CoV-2 isolate to create models of mild and severe disease in mice allowing us to dissect the role of necroptosis in SARS-CoV-2 disease pathogenesis.

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Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo - Cell Death & Disease

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Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo - Cell Death & Disease

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