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Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament - Nature Structural & Molecular Biology

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Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament - Nature Structural & Molecular Biology

Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration and membrane trafficking. Cortactin is important for actin branch stabilization, but the mechanism by which this occurs is unclear. Given this, we determined the structure of vertebrate cortactin-stabilized Arp2/3 actin branches using cryogenic electron microscopy. We

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Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament - Nature Structural & Molecular Biology

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Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament - Nature Structural & Molecular Biology

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