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Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis - Nature Cardiovascular Research

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Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis - Nature Cardiovascular Research

CCL17 is produced by conventional dendritic cells, signals through CCR4 on regulatory T (Treg) cells and drives atherosclerosis by suppressing Treg functions through yet undefined mechanisms. Here we show that conventional dendritic cells from CCL17-deficient mice display a pro-tolerogenic phenotype and transcriptome that is not phenocopied in mice lacking its cognate receptor CCR4. In the plasma of CCL17-deficient mice, CCL3 was the only decreased cytokine/chemokine.

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Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis - Nature Cardiovascular Research

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Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis - Nature Cardiovascular Research

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