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Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops - Nature Communications

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Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops - Nature Communications

Antibody derivatives have sought to recapitulate the antigen binding properties of antibodies, but with improved biophysical attributes convenient for therapeutic, diagnostic and research applications. However, their success has been limited by the naturally occurring structure of the immunoglobulin dimer displaying hypervariable binding loops, which is hard to modify by traditional engineering approaches.

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Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops - Nature Communications

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Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops - Nature Communications

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