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Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells - Nature Immunology

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Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells - Nature Immunology

The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune responses and clear infected cells will probably be necessary to achieve reduction of the latent reservoir. In the present study, we report two single-chain diabodies (scDbs) that target the HIV-1 envelope protein (Env) and the human type III Fcγ receptor (CD16).

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Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells - Nature Immunology

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Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells - Nature Immunology

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