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Caspase-dependent apoptosis in Ribloflavin transporter deficiency iPSCs and derived motor neurons - Cell Death Discovery

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Caspase-dependent apoptosis in Ribloflavin transporter deficiency iPSCs and derived motor neurons - Cell Death Discovery

Riboflavin Transporter Deficiency (RTD) is a rare genetic, childhood-onset disease. This pathology has a relevant neurological involvement, being characterized by motor symptoms, ponto-bulbar paralysis and sensorineural deafness. Such clinical presentation is associated with muscle weakness and motor neuron (MN) degeneration, so that RTD is considered part of the MN disease spectrum.

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Caspase-dependent apoptosis in Ribloflavin transporter deficiency iPSCs and derived motor neurons - Cell Death Discovery

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Caspase-dependent apoptosis in Ribloflavin transporter deficiency iPSCs and derived motor neurons - Cell Death Discovery

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