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Mammalian integrated stress responses in stressed organelles and their functions - Acta Pharmacologica Sinica

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Mammalian integrated stress responses in stressed organelles and their functions - Acta Pharmacologica Sinica

The integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions. Four kinases (PERK, PKR, GCN2, and HRI) of ISR regulate ISR signaling and intracellular protein translation via mediating the phosphorylation of eukaryotic translation initiation factor 2 α (eIF2α) at Ser51.

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Mammalian integrated stress responses in stressed organelles and their functions - Acta Pharmacologica Sinica

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Mammalian integrated stress responses in stressed organelles and their functions - Acta Pharmacologica Sinica

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