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HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization - Oncogene

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HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization - Oncogene

HJURP is overexpressed in several cancer types and strongly correlates with patient survival. However, the mechanistic basis underlying the association of HJURP with cancer aggressiveness is not well understood. HJURP promotes the loading of the histone H3 variant, CENP-A, at the centromeric chromatin, epigenetically defining the centromeres and supporting proper chromosome segregation. In addition, HJURP is associated with DNA repair but its function in this process is still scarcely explored.

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HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization - Oncogene

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HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization - Oncogene

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