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Multiregion sampling of de novo metastatic prostate cancer reveals complex polyclonality and augments clinical genotyping - Nature Cancer

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Multiregion sampling of de novo metastatic prostate cancer reveals complex polyclonality and augments clinical genotyping - Nature Cancer

De novo metastatic prostate cancer is highly aggressive, but the paucity of routinely collected tissue has hindered genomic stratification and precision oncology. Here, we leveraged a rare study of surgical intervention in 43 de novo metastatic prostate cancers to assess somatic genotypes across 607 synchronous primary and metastatic tissue regions plus circulating tumor DNA.

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Multiregion sampling of de novo metastatic prostate cancer reveals complex polyclonality and augments clinical genotyping - Nature Cancer

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Multiregion sampling of de novo metastatic prostate cancer reveals complex polyclonality and augments clinical genotyping - Nature Cancer

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