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Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis - npj Systems Biology and Applications

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Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis - npj Systems Biology and Applications

Macrophages play an essential role in rheumatoid arthritis. Depending on their phenotype (M1 or M2), they can play a role in the initiation or resolution of inflammation. The M1/M2 ratio in rheumatoid arthritis is higher than in healthy controls. Despite this, no treatment targeting specifically macrophages is currently used in clinics. Thus, devising strategies to selectively deplete proinflammatory macrophages and promote anti-inflammatory macrophages could be a promising therapeutic approach.

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Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis - npj Systems Biology and Applications

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