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Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria - Nature Immunology

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Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria - Nature Immunology

The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses antitumor T cell immunity. However, LA is a natural energy metabolite that can be oxidized in the mitochondria and could potentially stimulate T cells. Here we show that the lactate-lowering mood stabilizer lithium carbonate (LC) can inhibit LA-mediated CD8+ T cell immunosuppression. Cytoplasmic LA increased the pumping of protons into lysosomes.

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Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria - Nature Immunology

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Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria - Nature Immunology

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