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A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling - Communications Biology

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A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling - Communications Biology

Neudesin, originally identified as a neurotrophic factor, has primarily been studied for its neural functions despite its widespread expression. Using 8-week-old neudesin knockout mice, we elucidated the role of neudesin in the spleen. The absence of neudesin caused mild splenomegaly, shortened lifespan of circulating erythrocytes, and abnormal recovery from phenylhydrazine-induced acute anemia.

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A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling - Communications Biology

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A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling - Communications Biology

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