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Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas - Nature Communications

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Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas - Nature Communications

Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional immune signaling. However, little is known about the interplay between ATRX loss and IDH mutation on innate immunity. To explore this, we generated ATRX-deficient glioma models in the presence and absence of the IDH1R132H mutation.

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Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas - Nature Communications

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Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas - Nature Communications

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