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Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer - Oncogene

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Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer - Oncogene

WEE1 and CHEK1 (CHK1) kinases are critical regulators of the G2/M cell cycle checkpoint and DNA damage response pathways. The WEE1 inhibitor AZD1775 and the CHK1 inhibitor SRA737 are in clinical trials for various cancers, but have not been thoroughly examined in prostate cancer, particularly castration-resistant (CRPC) and neuroendocrine prostate cancers (NEPC). Our data demonstrated elevated WEE1 and CHK1 expressions in CRPC and NEPC cell lines and patient samples.

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Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer - Oncogene

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Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer - Oncogene

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