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SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling - Cell Death & Disease

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SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling - Cell Death & Disease

Cancer cells alter their metabolism and epigenetics to support cancer progression. However, very few modulators connecting metabolism and epigenetics have been uncovered. Here, we reveal that serine hydroxymethyltransferase-2 (SHMT2) generates S-adenosylmethionine (SAM) to epigenetically repress phosphatase and tensin homolog (PTEN), leading to papillary thyroid cancer (PTC) metastasis depending on activation of AKT signaling. SHMT2 is elevated in PTC, and is associated with poor prognosis.

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SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling - Cell Death & Disease

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SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling - Cell Death & Disease

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