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Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition - Nature Cell Biology

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Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition - Nature Cell Biology

The gut microbiota play a pivotal role in human health. Emerging evidence indicates that gut microbes participate in the progression of tumorigenesis through the generation of carcinogenic metabolites. However, the underlying molecular mechanism is largely unknown. In the present study we show that a tryptophan metabolite derived from Peptostreptococcus anaerobius, trans-3-indoleacrylic acid (IDA), facilitates colorectal carcinogenesis.

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Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition - Nature Cell Biology

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Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition - Nature Cell Biology

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