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Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders - Nature Cell Biology

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Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders - Nature Cell Biology

Lysosomal storage disorders (LSDs), which are characterized by genetic and metabolic lysosomal dysfunctions, constitute over 60 degenerative diseases with considerable health and economic burdens. However, the mechanisms driving the progressive death of functional cells due to lysosomal defects remain incompletely understood, and broad-spectrum therapeutics against LSDs are lacking.

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Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders - Nature Cell Biology

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Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders - Nature Cell Biology

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