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Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing - Nature Metabolism

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Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing - Nature Metabolism

The global loss of heterochromatin during ageing has been observed in eukaryotes from yeast to humans, and this has been proposed as one of the causes of ageing. However, the cause of this age-associated loss of heterochromatin has remained enigmatic. Here we show that heterochromatin markers, including histone H3K9 di/tri-methylation and HP1, decrease with age in muscle stem cells (MuSCs) as a consequence of the depletion of the methyl donor S-adenosylmethionine (SAM). We

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Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing - Nature Metabolism

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Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing - Nature Metabolism

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