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Causality-enriched epigenetic age uncouples damage and adaptation - Nature Aging

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Causality-enriched epigenetic age uncouples damage and adaptation - Nature Aging

Machine learning models based on DNA methylation data can predict biological age but often lack causal insights. By harnessing large-scale genetic data through epigenome-wide Mendelian randomization, we identified CpG sites potentially causal for aging-related traits. Neither the existing epigenetic clocks nor age-related differential DNA methylation are enriched in these sites.

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Causality-enriched epigenetic age uncouples damage and adaptation - Nature Aging

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Causality-enriched epigenetic age uncouples damage and adaptation - Nature Aging

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