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Imbuing peptide libraries with drug-likeness - Nature Chemical Biology

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Imbuing peptide libraries with drug-likeness - Nature Chemical Biology

The rules for designing cyclic peptides with drug-like properties are unclear. Two studies now show how cyclic peptide libraries can be created to optimize properties such as cell permeability before screening for binding activity. The approach has led to a macrocyclic peptide inhibitor for KRAS that has reached clinical trials.

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Imbuing peptide libraries with drug-likeness - Nature Chemical Biology

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Imbuing peptide libraries with drug-likeness - Nature Chemical Biology

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