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The nucleolar shell provides anchoring sites for DNA untwisting - Communications Biology

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The nucleolar shell provides anchoring sites for DNA untwisting - Communications Biology

DNA underwinding (untwisting) is a crucial step in transcriptional activation. DNA underwinding occurs between the site where torque is generated by RNA polymerase (RNAP) and the site where the axial rotation of DNA is constrained. However, what constrains DNA axial rotation in the nucleus is yet unknown. Here, we show that the anchorage to the nuclear protein condensates constrains DNA axial rotation for DNA underwinding in the nucleolus.

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The nucleolar shell provides anchoring sites for DNA untwisting - Communications Biology

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The nucleolar shell provides anchoring sites for DNA untwisting - Communications Biology

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