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Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids - Nature Microbiology

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Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids - Nature Microbiology

A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain largely unknown. Here we report that the gut commensal Christensenella minuta modulates host metabolism by generating a previously undescribed class of secondary bile acids with 3-O-acylation substitution that inhibit the intestinal farnesoid X receptor.

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Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids - Nature Microbiology

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Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids - Nature Microbiology

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