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The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function - Cell Death & Disease

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The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function - Cell Death & Disease

MitoKATP is a channel of the inner mitochondrial membrane that controls mitochondrial K+ influx according to ATP availability. Recently, the genes encoding the pore-forming (MITOK) and the regulatory ATP-sensitive (MITOSUR) subunits of mitoKATP were identified, allowing the genetic manipulation of the channel. Here, we analyzed the role of mitoKATP in determining skeletal muscle structure and activity.

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The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function - Cell Death & Disease

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The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function - Cell Death & Disease

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