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Profiling the interactome of oligonucleotide drugs by proximity biotinylation - Nature Chemical Biology

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Profiling the interactome of oligonucleotide drugs by proximity biotinylation - Nature Chemical Biology

Drug-ID is a novel method applying proximity biotinylation to identify drug–protein interactions inside living cells. The covalent conjugation of a drug with a biotin ligase enables targeted biotinylation and identification of the drug-bound proteome. We established Drug-ID for two small-molecule drugs, JQ1 and SAHA, and applied it for RNaseH-recruiting antisense oligonucleotides (ASOs).

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Profiling the interactome of oligonucleotide drugs by proximity biotinylation - Nature Chemical Biology

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Profiling the interactome of oligonucleotide drugs by proximity biotinylation - Nature Chemical Biology

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