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Implications of stress-induced gene expression for hematopoietic stem cell aging studies - Nature Aging

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Implications of stress-induced gene expression for hematopoietic stem cell aging studies - Nature Aging

A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.

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Implications of stress-induced gene expression for hematopoietic stem cell aging studies - Nature Aging

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Implications of stress-induced gene expression for hematopoietic stem cell aging studies - Nature Aging

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