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Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets - Nature Reviews Cardiology

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Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets - Nature Reviews Cardiology

Atherosclerosis is a progressive inflammatory disorder of the arterial vessel wall characterized by substantial infiltration of macrophages, which exert both favourable and detrimental functions. Early in atherogenesis, macrophages can clear cytotoxic lipoproteins and dead cells, preventing cytotoxicity. Efferocytosis — the efficient clearance of dead cells by macrophages — is crucial for preventing secondary necrosis and stimulating the release of anti-inflammatory cytokines.

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Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets - Nature Reviews Cardiology

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Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets - Nature Reviews Cardiology

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