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GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome - Nature Cardiovascular Research

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GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome - Nature Cardiovascular Research

Viral myocarditis is characterized by infiltration of mononuclear cells essential for virus elimination. GPR15 has been identified as a homing receptor for regulatory T cells in inflammatory intestine diseases, but its role in inflammatory heart diseases is still elusive. Here we show that GPR15 deficiency impairs coxsackievirus B3 elimination, leading to adverse cardiac remodeling and dysfunction.

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GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome - Nature Cardiovascular Research

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GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome - Nature Cardiovascular Research

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