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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules - Nature Structural & Molecular Biology
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Targeted protein degradation (TPD) by PROTAC (proteolysis-targeting chimera) and molecular glue small molecules is an emerging therapeutic strategy. To expand the roster of E3 ligases that can be utilized for TPD, we describe the discovery and biochemical characterization of small-molecule ligands targeting the E3 ligase KLHDC2.
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