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Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis - Signal Transduction and Targeted Therapy

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Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis - Signal Transduction and Targeted Therapy

Systemic lupus erythematosus (SLE), a severe autoimmune disorder, is characterized by systemic inflammatory response, autoantibody accumulation and damage to organs. The dysregulation of double-negative (DN) T cells is considered as a crucial commander during SLE. Neddylation, a significant type of protein post-translational modification (PTM), has been well-proved to regulate T cell-mediated immune response. However, the function of neddylation in SLE is still unknown.

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Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis - Signal Transduction and Targeted Therapy

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Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis - Signal Transduction and Targeted Therapy

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