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Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites - Nature Chemical Biology

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Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites - Nature Chemical Biology

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent protein lysine deacylases regulating metabolism and stress responses; however, characterization of the removed acyl groups and their downstream metabolic fates remains incomplete. Here we employed untargeted comparative metabolomics to reinvestigate mitochondrial sirtuin biochemistry.

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Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites - Nature Chemical Biology

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Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites - Nature Chemical Biology

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