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Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis - Acta Pharmacologica Sinica

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Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis - Acta Pharmacologica Sinica

Osteoporosis results from overactivation of osteoclasts. There are currently few drug options for treatment of this disease. Since the successful development of allosteric inhibitors, phosphatases have become attractive therapeutic targets. Protein phosphatase 1, regulatory subunit 15 A (PPP1R15A), is a stress-responsive protein, which promotes the UPR (unfolded protein response) and restores protein homeostasis.

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Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis - Acta Pharmacologica Sinica

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Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis - Acta Pharmacologica Sinica

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