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Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation - Cell Research

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Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation - Cell Research

Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the mechanism that balances OXPHOS activity and intracellular oxygen availability remains elusive. Here, we report that mitochondrial protein lactylation is induced by intracellular hypoxia to constrain OXPHOS.

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Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation - Cell Research

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Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation - Cell Research

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