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MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis - Nature

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MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis - Nature

Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS–STING-mediated signalling and tumour suppression1–3. However, the precise mechanism of cGAS activation by endogenous DNA damage remains enigmatic, particularly given that high-affinity histone acidic patch (AP) binding constitutively inhibits cGAS by sterically hindering its activation by double-stranded DNA (dsDNA)4–10.

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MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis - Nature

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MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis - Nature

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