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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts - Nature Communications

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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts - Nature Communications

Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs). Here we show that TRCs trigger a DNA Damage Response (DDR) involving the chromatin network to prevent genome instability.

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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts - Nature Communications

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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts - Nature Communications

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