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Palmitate induces integrated stress response and lipoapoptosis in trophoblasts - Cell Death & Disease

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Palmitate induces integrated stress response and lipoapoptosis in trophoblasts - Cell Death & Disease

Maternal obesity increases the risk of childhood obesity and programs the offspring to develop metabolic syndrome later in their life. Palmitate is the predominant saturated free fatty acid (FFA) that is transported across the placenta to the fetus. We have recently shown that saturated FFA in the maternal circulation as a result of increased adipose tissue lipolysis in third trimester of pregnancy induces trophoblast lipoapoptosis.

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Palmitate induces integrated stress response and lipoapoptosis in trophoblasts - Cell Death & Disease

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Palmitate induces integrated stress response and lipoapoptosis in trophoblasts - Cell Death & Disease

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