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Targeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma - Leukemia

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Targeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma - Leukemia

S-palmitoylation is essential for cancer development via regulating protein stability, function and subcellular location, yet the roles S-palmitoylation plays in diffuse large B-cell lymphoma (DLBCL) progression remain enigmatic. In this study, we uncovered a novel function of the palmitoyltransferase ZDHHC21 as a tumor suppressor in DLBCL and identified ZDHHC21 as a key regulator of fatty acid synthetase (FASN) S-palmitoylation for the first time.

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Targeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma - Leukemia

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Targeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma - Leukemia

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