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Accelerating the discovery of alkyl halide-derived natural products using halide depletion - Nature Chemistry

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Accelerating the discovery of alkyl halide-derived natural products using halide depletion - Nature Chemistry

Even in the genomic era, microbial natural product discovery workflows can be laborious and limited in their ability to target molecules with specific structural features. Here we leverage an understanding of biosynthesis to develop a workflow that targets the discovery of alkyl halide-derived natural products by depleting halide anions, a key biosynthetic substrate for enzymatic halogenation, from microbial growth media.

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Accelerating the discovery of alkyl halide-derived natural products using halide depletion - Nature Chemistry

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Accelerating the discovery of alkyl halide-derived natural products using halide depletion - Nature Chemistry

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