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EPAC1 enhances brown fat growth and beige adipogenesis - Nature Cell Biology

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EPAC1 enhances brown fat growth and beige adipogenesis - Nature Cell Biology

Brown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure and cardiometabolic health. However, regulators that specifically increase the number of thermogenic adipocytes are still an unmet need. Here, we show that the cAMP-binding protein EPAC1 is a central regulator of adaptive BAT growth. In vivo, selective pharmacological activation of EPAC1 increases BAT mass and browning of white fat, leading to higher energy expenditure and reduced diet-induced obesity.

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EPAC1 enhances brown fat growth and beige adipogenesis - Nature Cell Biology

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EPAC1 enhances brown fat growth and beige adipogenesis - Nature Cell Biology

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