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The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression - Nature Metabolism

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The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression - Nature Metabolism

Bone-resorbing osteoclasts are vital for postnatal bone health, as increased differentiation or activity results in skeletal pathologies such as osteoporosis. The metabolism of mature osteoclasts differs from their progenitor cells, but whether the observed metabolic changes are secondary to the altered cell state or actively drive the process of cell differentiation is unknown.

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The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression - Nature Metabolism

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The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression - Nature Metabolism

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