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Nutrient uptake strategies shift during mouse epiblast development - Nature Metabolism

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Nutrient uptake strategies shift during mouse epiblast development - Nature Metabolism

Murine blastocysts and embryonic stem cells mimicking the pre-implantation epiblast import extracellular protein through macropinocytosis and engage a robust lysosomal digestive programme to meet their nutrient demands. We found that as development proceeds, post-implantation epiblast-like cells downregulate protein digestion, increase expression of amino acid transporters and become dependent on soluble amino acids.

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Nutrient uptake strategies shift during mouse epiblast development - Nature Metabolism

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Nutrient uptake strategies shift during mouse epiblast development - Nature Metabolism

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