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PRKCSH contributes to TNFSF resistance by extending IGF1R half-life and activation in lung cancer - Experimental & Molecular Medicine

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PRKCSH contributes to TNFSF resistance by extending IGF1R half-life and activation in lung cancer - Experimental & Molecular Medicine

Tumor necrosis factor superfamily (TNFSF) resistance contributes to the development and progression of tumors and resistance to various cancer therapies. Tumor-intrinsic alterations involved in the adaptation to the TNFSF response remain largely unknown. Here, we demonstrate that protein kinase C substrate 80K-H (PRKCSH) abundance in lung cancers boosts oncogenic IGF1R activation, leading to TNFSF resistance. PRKCSH abundance is correlated with IGF1R upregulation in lung cancer tissues.

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PRKCSH contributes to TNFSF resistance by extending IGF1R half-life and activation in lung cancer - Experimental & Molecular Medicine

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PRKCSH contributes to TNFSF resistance by extending IGF1R half-life and activation in lung cancer - Experimental & Molecular Medicine

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