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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo - Nature Biotechnology

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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo - Nature Biotechnology

Prime editing enables precise installation of genomic substitutions, insertions and deletions in living systems. Efficient in vitro and in vivo delivery of prime editing components, however, remains a challenge. Here we report prime editor engineered virus-like particles (PE-eVLPs) that deliver prime editor proteins, prime editing guide RNAs and nicking single guide RNAs as transient ribonucleoprotein complexes.

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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo - Nature Biotechnology

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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo - Nature Biotechnology

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